Stem Cells and 3D Printing - Advances in Pelvic Health with Professor Caroline Gargett

Professor Caroline Gargett, PhD, is a National Health and Medical Research Council of Australia Leadership Fellow, Women’s Health Theme Leader and heads the Endometrial Stem Cell Biology Laboratory at the Hudson Institute of Medical Research and an adjunct Professor in the Department of Obstetrics and Gynaecology, Monash University. She discovered endometrial stem/progenitor cells and investigates their role in endometrial biology, endometriosis and is developing a bioengineered cell-based therapy for treating and preventing Pelvic Organ Prolapse using endometrial mesenchymal stem cells and novel biomaterials. Her awards include the Society for Reproductive Investigation President’s Achievement Award (2013), the Endometriosis Foundation of America Honoree (2011), Fellow of the Society for Reproductive Biology (2017) and co-recipient of the $1M Magee Prize for a Vaginal Stem Cells Study She is a Director of the National Stem Cell Foundation of Australia and Stem Cells Limited and Scientific Advisory Board member of the Endometriosis Foundation of America, Fondation Pour la Recherche sur Endometriose, France. She was President of the Australasian Society for Stem Cell Research (2013-2014) and Secretary of the Society for Reproductive Biology (2005-2008). She has authored 155 publications.

Currently she is an Editorial Board member of Scientific Reports, Reviewing Board Member for Biology of Reproduction and former Editorial Board Member and Associate Editor for Reproductive Sciences. She previously served as Associate Editor for Fertility and Sterility and Human Reproduction.

IMPACT OF OUR POP RESEARCH

Prof Gargett is developing the first cell-based bioengineered therapy for Pelvic Organ Prolapse (POP) using eMSC and new biomaterials. The impact of the knowledge generated in evaluating their new bioengineered therapy in a rat model of “POP” repair (2014) was the initiation of a new line of research in Urogynaecology. She and now others have progressed her pioneering research to large animal vaginal surgery models of POP, nanotechnologies and 3D (bio)printing. She trained 3 gynaecologists in this new technology, one received 3 International awards, was invited to present at a Gordon Research Conference (2016) and leads a research group in Graz, Austria. She secured 3 CIA NHMRC Project, Investigator & SIEF grants for our POP research and given 14 international invited presentations, including The Royal Society, London (2017) and IUGA Clinical Conference (2020, 2019, 2018, 2022) and was invited to join IUGA Steering Committee to create a Basic Science/Translational Research Special Interest Group and presented in the inaugural IUGA Basic Science Symposium in 2020.

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